Water deprivation test in the dog: maximal normal values.

Studies were undertaken to determine maximal urine osmolality and urine specific gravity following water deprivation for 20 dogs with normal renal function. In addition, the reliability of body weight, skin pliability, total plasma protein concentration, and packed cell volume as indices of negative water balance was assessed. Following water deprivation for periods sufficient to induce dehydration, the mean maximal urine osmolality was 2,289 mOsm/kg. The corresponding mean maximal urine specific gravity was 1.062 and ranged from 1.050 to 1.076. The ratio of mean maximal urine osmolality to mean serum osmolality at the time of peak urine concentration was 7.3. There was no detectable difference in urine concentration indices between males and females. Changes in skin pliability and packed cell volume proved unreliable as estimates of dehydration. Weight loss and increases in total plasma protein concentration proved to be more consistent indicators of hydration status. Abnormal increases in serum urea nitrogen and serum creatinine concentrations occurred rarely, even though some dogs had water withheld for periods of up to 96 hours.