Knoche E, Biebl A, Dick W
Infusionsther Klin Ernahr. 1981 Oct;8(5):224-32.
This clinical investigation was carried out in order to determine whether the 10-12 hr food and fluid restrictions imposed before elective operations have detrimental effects on older patients according to various metabolic parameters. Thirty male urological patients aged between 60 and 90 years were chosen for study (group I 60-70 years, group II 70-80 years, group III 89-90 years). The following parameters were measured at 7 p.m. the evening before the operation, and at 7. a.m. on the morning of operation: body weight, hematocrit, blood-gas analysis, electrolytes, serum osmolality, urea, creatinine, total protein with electrophoresis and blood glucose. Urine was collected during the period of abstinence and osmolality, electrolytes, total nitrogen, creatinine and urea were estimated. All patients showed a reduced creatinine clearance to a degree that was expected for their age. In all three groups a significant weight reduction (p less than 0,001) occurred during the time of observation. The 12 hr urine volume increased from one age group to the next whereas perspiration decreased, indicating deficient thermal regulations in older patients. The hypohydration on the morning of operation, especially in group II and III, marked a relatively lower hematocrit and hypoproteinemia. In all three groups the urea and creatinine values were slightly lower in the morning than in the evening before, indicating the occurrence of further hypohydration due to fasting. The low elimination of total nitrogen, urea, and creatinine in the urine could be an indication that the 12 hr food and fluid restriction caused no marked catabolism. Our study shows that geriatric patients are indeed able to compensate for a 12 hr-period of abstinence. When however, these patients also have to undergo an operation, possibly associated with a considerable loss of body fluids or when restriction of oral intake extends to 16-20 hrs, decompensation may rapidly occur leading to deleterious consequences.
进行这项临床研究是为了根据各种代谢参数确定择期手术前实施的10 - 12小时食物和液体限制对老年患者是否有不利影响。选择了30名年龄在60至90岁之间的男性泌尿外科患者进行研究(第一组60 - 70岁,第二组70 - 80岁,第三组89 - 90岁)。在手术前一晚的晚上7点以及手术当天上午7点测量以下参数:体重、血细胞比容、血气分析、电解质、血清渗透压、尿素、肌酐、总蛋白及电泳和血糖。在禁食期间收集尿液,并测定尿渗透压、电解质、总氮、肌酐和尿素。所有患者的肌酐清除率均有所降低,降低程度与他们的年龄相符。在所有三组中,观察期间体重均显著下降(p小于0.001)。12小时尿量从一个年龄组到下一个年龄组增加,而出汗量减少,这表明老年患者的体温调节功能不足。手术当天上午的脱水状态,尤其是第二组和第三组,表现为血细胞比容相对较低和低蛋白血症。在所有三组中,上午的尿素和肌酐值略低于前一晚,表明禁食导致进一步脱水。尿液中总氮、尿素和肌酐的排泄量低可能表明12小时的食物和液体限制未引起明显的分解代谢。我们的研究表明,老年患者确实能够补偿12小时的禁食期。然而,当这些患者还必须接受手术,可能伴有大量体液流失,或者口服摄入量限制延长至16 - 20小时时,可能会迅速出现失代偿,导致有害后果。