Wassef M R, Lal H, Pleuvry B J
Br J Anaesth. 1974 Jul;46(7):473-8. doi: 10.1093/bja/46.7.473.
The cardiovascular effects of ergometrine have been examined using animal models in vivo and in vitro. In rats in vivo the pressor effects of a standard dose of ergometrine were found to be dependent upon the anaesthetic used for the procedure. The pressor action of ergometrine was greater when urethane, an anaesthetic which produces both sympathetic and parasympathetic acitivity, was used. The in-vitro experiments, using isolated rabbit aorta and portal vein, failed to explain the phenomenon; they suggested that ergometrine has a direct action on the alpha-adrenoceptor in rabbits. No evidence was found to suggest that ergometrine inhibits noradrenaline uptake or its release from the nerve terminals.
已使用体内和体外动物模型研究了麦角新碱的心血管效应。在体内实验中，给大鼠注射标准剂量的麦角新碱，发现其升压作用取决于手术所使用的麻醉剂。当使用能同时产生交感神经和副交感神经活性的麻醉剂乌拉坦时，麦角新碱的升压作用更强。使用离体兔主动脉和门静脉进行的体外实验未能解释这一现象；这些实验表明麦角新碱对兔的α-肾上腺素能受体有直接作用。未发现有证据表明麦角新碱会抑制去甲肾上腺素的摄取或其从神经末梢的释放。
