3-亚甲基氧化吲哚的抗病毒活性
Antiviral activity of 3-methyleneoxindole.
作者信息
Tuli V, Moyed H S, Stevenson D, Gordon I
出版信息
Antimicrob Agents Chemother. 1974 May;5(5):479-84. doi: 10.1128/AAC.5.5.479.
Abstract
3-Methyleneoxindole (MO), an oxidation product of the plant auxin indole-3-acetic acid, can selectively inhibit the replication of herpes-, mengo-, polioviruses, and Sindbis virus. The antiviral action of MO, a sulfhydryl binding compound, is neutralized by 2-mercaptoethanol if the latter is added soon after exposure of infected cells to MO. If addition of 2-mercaptoethanol is delayed, the antiviral action of MO appears to be irreversible. Data are presented which indicate that the antiviral action of MO is not mediated by interferon.
摘要
3-亚甲基氧化吲哚（MO）是植物生长素吲哚-3-乙酸的氧化产物，能选择性抑制疱疹病毒、门戈病毒、脊髓灰质炎病毒和辛德毕斯病毒的复制。MO是一种巯基结合化合物，其抗病毒作用在感染细胞接触MO后不久加入2-巯基乙醇时会被中和。如果延迟加入2-巯基乙醇，MO的抗病毒作用似乎是不可逆的。所提供的数据表明，MO的抗病毒作用不是由干扰素介导的。
相似文献
1
Antiviral activity of 3-methyleneoxindole.3-亚甲基氧化吲哚的抗病毒活性
Antimicrob Agents Chemother. 1974 May;5(5):479-84. doi: 10.1128/AAC.5.5.479.
2
Mechanism of the antiviral action of 3-methyleneoxindole.3-亚甲基氧化吲哚的抗病毒作用机制。
Antimicrob Agents Chemother. 1974 May;5(5):485-91. doi: 10.1128/AAC.5.5.485.
3
Antiviral activity of hetarylhydrazones.
Acta Virol. 1982 May;26(3):130-6.
4
Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.广谱抗病毒药物，干扰从头合成嘧啶核苷酸。
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5777-82. doi: 10.1073/pnas.1101143108. Epub 2011 Mar 21.
5
Auxin activity of 3-methyleneoxindole in wheat.3-亚甲基氧吲哚在小麦中的生长素活性。
Plant Physiol. 1972 Oct;50(4):499-502. doi: 10.1104/pp.50.4.499.
6
The Binding of Indole-3-acetic Acid and 3-Methyleneoxindole to Plant Macromolecules.吲哚-3-乙酸和 3-亚甲基氧茚满与植物大分子的结合。
Plant Physiol. 1972 Oct;50(4):507-9. doi: 10.1104/pp.50.4.507.
7
[On the biological action of transition metal complexes. 2. The antiviral activity of 4-methyl-2-amino-pyridine-palladium-chloride (IV)].[关于过渡金属配合物的生物作用。2. 4-甲基-2-氨基吡啶氯化钯（IV）的抗病毒活性]
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981;249(4):421-30.
8
Inhibition of cellular and viral protein synthesis by 3-methyleneoxindole.3-亚甲基氧化吲哚对细胞和病毒蛋白质合成的抑制作用。
Antimicrob Agents Chemother. 1977 Mar;11(3):521-7. doi: 10.1128/AAC.11.3.521.
9
[Effect of various indole derivatives with thiazolidine substituents on influenza virus].
Farm Zh. 1970;25(5):58-60.
10
[On the biological action of transition metal complexes. 3. About the antiviral activity of cis-dichloro diammine platinum (II) (author's transl)].[关于过渡金属配合物的生物作用。3. 顺二氯二氨合铂（II）的抗病毒活性（作者译）]
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1981 Nov;250(4):417-24.
引用本文的文献
1
Investigation of vitamin B₆ inadequacy, induced by exposure to the anti-B₆ factor 1-amino D-proline, on plasma lipophilic metabolites of rats: a metabolomics approach.暴露于抗维生素B₆因子1-氨基-D-脯氨酸诱导的大鼠维生素B₆缺乏对其血浆亲脂性代谢物的影响：代谢组学方法
Eur J Nutr. 2016 Apr;55(3):1213-23. doi: 10.1007/s00394-015-0934-x. Epub 2015 May 26.
2
Mechanism of the antiviral action of 3-methyleneoxindole.3-亚甲基氧化吲哚的抗病毒作用机制。
Antimicrob Agents Chemother. 1974 May;5(5):485-91. doi: 10.1128/AAC.5.5.485.
3
Inhibition of cellular and viral protein synthesis by 3-methyleneoxindole.3-亚甲基氧化吲哚对细胞和病毒蛋白质合成的抑制作用。
Antimicrob Agents Chemother. 1977 Mar;11(3):521-7. doi: 10.1128/AAC.11.3.521.
本文引用的文献
1
The Binding of Indole-3-acetic Acid and 3-Methyleneoxindole to Plant Macromolecules.吲哚-3-乙酸和 3-亚甲基氧茚满与植物大分子的结合。
Plant Physiol. 1972 Oct;50(4):507-9. doi: 10.1104/pp.50.4.507.
2
Auxin activity of 3-methyleneoxindole in wheat.3-亚甲基氧吲哚在小麦中的生长素活性。
Plant Physiol. 1972 Oct;50(4):499-502. doi: 10.1104/pp.50.4.499.
3
Inhibitory oxidation products of indole-3-acetic Acid: 3-hydroxymethyloxindole and 3-methyleneoxindole as plant metabolites.吲哚-3-乙酸的抑制性氧化产物：3-羟甲基吲哚酮和3-亚甲基吲哚酮作为植物代谢物。
Plant Physiol. 1967 Mar;42(3):425-30. doi: 10.1104/pp.42.3.425.
4
5
ELECTRON MICROSCOPIC STUDY OF THE FORMATION OF POLIOVIRUS.脊髓灰质炎病毒形成的电子显微镜研究
Virology. 1965 Jul;26:379-89. doi: 10.1016/0042-6822(65)90001-2.
6
INHIBITORY OXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID. MECHANISM OF ACTION AND ROUTE OF DETOXIFICATION.吲哚-3-乙酸的抑制性氧化产物。作用机制与解毒途径。
J Biol Chem. 1965 Jun;240:2612-8.
7
INHIBITION OF CELL GROWTH BY PHOTOOXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID.吲哚-3-乙酸光氧化产物对细胞生长的抑制作用
J Biol Chem. 1964 Jul;239:2392-7.
8
Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
Science. 1959 Aug 21;130(3373):432-7. doi: 10.1126/science.130.3373.432.
9
3-Methyleneoxindole reductase of peas.豌豆的3-亚甲基氧化吲哚还原酶
Plant Physiol. 1967 Apr;42(4):510-4. doi: 10.1104/pp.42.4.510.
10
The role of 3-methyleneoxindole in auxin action.3-亚甲基氧化吲哚在生长素作用中的作用。
J Biol Chem. 1969 Sep 25;244(18):4916-20.
Zotero 插件