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Biochem J. 1974 Dec;144(3):601-3. doi: 10.1042/bj1440601.
2
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Neurotransmitter and monoaminergic amino acid precursor levels in rat brain: effects of chronic renal failure and of malnutrition.大鼠脑中神经递质和单胺能氨基酸前体水平：慢性肾衰竭和营养不良的影响。
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引用本文的文献

1
Rapid development of oedema and defective brain histidine metabolism in young guinea pigs fed protein-energy deficient diet.喂食蛋白质 - 能量缺乏饮食的幼年豚鼠出现水肿快速发展和脑组氨酸代谢缺陷。
Br J Exp Pathol. 1983 Oct;64(5):487-96.

本文引用的文献

1
Histidine metabolism in experimental protein malnutrition in rats.大鼠实验性蛋白质营养不良中的组氨酸代谢
Biochem J. 1965 Oct;97(1):311-7. doi: 10.1042/bj0970311.
2
AMINO ACID METABOLISM IN KWASHIORKOR. I. METABOLISM OF HISTIDINE AND IMIDAZOLE DERIVATIVES.恶性营养不良时的氨基酸代谢。I. 组氨酸及咪唑衍生物的代谢
Clin Sci. 1964 Apr;26:271-8.
3
EFFECT OF AMINO ACIDS ON UPTAKE OF L-HISTIDINE BY RAT BRAIN SLICES.氨基酸对大鼠脑切片摄取L-组氨酸的影响。
J Neurochem. 1964 Feb;11:67-76. doi: 10.1111/j.1471-4159.1964.tb06743.x.
4
Transamination of aromatic amino-acids in nervous tissue.神经组织中芳香族氨基酸的转氨作用。
Nature. 1962 Nov 10;196:577-8. doi: 10.1038/196577a0.
5
Control of cerebral metabolite levels. I. Amino acid uptake and levels in various species.脑代谢物水平的调控。I. 不同物种中的氨基酸摄取与水平
Arch Biochem Biophys. 1967 Mar;119(1):303-11. doi: 10.1016/0003-9861(67)90460-2.
6
Circadian rhythms in rat mid-brain and caudate nucleus biogenic amine levels.大鼠中脑和尾状核生物胺水平的昼夜节律。
J Physiol. 1968 Jul;197(1):77-85. doi: 10.1113/jphysiol.1968.sp008547.
7
Studies of hepatic lesions of experimental protein-calorie malnutrition in rats and immediate effects of refeeding an adequate protein diet.大鼠实验性蛋白质 - 热量营养不良的肝脏病变及重新给予充足蛋白质饮食的即时影响的研究。
J Nutr. 1971 Apr;101(4):501-14. doi: 10.1093/jn/101.4.501.
8
Nutrition and man's intellect and behavior.营养与人类的智力和行为。
Fed Proc. 1971 Jul-Aug;30(4):1429-33.
9
Properties and regional distribution of histidine decarboxylase in rat brain.大鼠脑中组氨酸脱羧酶的性质与区域分布
J Neurochem. 1970 Nov;17(11):1527-34. doi: 10.1111/j.1471-4159.1970.tb03722.x.
10
Experimental protein-calorie malnutrition in rats. Biochemical and ultrastructural studies.大鼠实验性蛋白质-热量营养不良。生化与超微结构研究。
Exp Mol Pathol. 1970 Jun;12(3):332-53. doi: 10.1016/0014-4800(70)90065-1.

膳食蛋白质营养不良期间豚鼠和大鼠大脑中组胺的浓度。

Concentrations of histamine in brain of guinea pig and rat during dietary protein malnutrition.

作者信息

Enwonwu C O, Worthington B S

出版信息

Biochem J. 1974 Dec;144(3):601-3. doi: 10.1042/bj1440601.

DOI:10.1042/bj1440601
PMID:4478801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168540/
Abstract

Protein malnutrition produced marked elevations in brain contents of histamine in guinea pigs (+142%) and rats (+257%) in comparison with findings in the control adequately fed animals. Associated with accumulation of this biogenic amine in each set of animals was an increase of similar magnitude in brain content of free histidine. It was concluded that the elevated brain content of histamine in protein malnutrition was due mainly to increased availability of the precursor amino acid, and that such alterations in amounts of neurotransmitter amines in the central nervous system might underlie some of the behavioural abnormalities seen in malnourished animals.

摘要

与正常喂食的对照动物相比，蛋白质营养不良使豚鼠（增加142%）和大鼠（增加257%）大脑中的组胺含量显著升高。每组动物中，这种生物胺的积累伴随着游离组氨酸脑含量的同等程度增加。得出的结论是，蛋白质营养不良时大脑中组胺含量升高主要是由于前体氨基酸的可用性增加，并且中枢神经系统中神经递质胺量的这种变化可能是营养不良动物出现某些行为异常的原因。