膳食蛋白质营养不良期间豚鼠和大鼠大脑中组胺的浓度。
Concentrations of histamine in brain of guinea pig and rat during dietary protein malnutrition.
作者信息
Enwonwu C O, Worthington B S
出版信息
Biochem J. 1974 Dec;144(3):601-3. doi: 10.1042/bj1440601.
Protein malnutrition produced marked elevations in brain contents of histamine in guinea pigs (+142%) and rats (+257%) in comparison with findings in the control adequately fed animals. Associated with accumulation of this biogenic amine in each set of animals was an increase of similar magnitude in brain content of free histidine. It was concluded that the elevated brain content of histamine in protein malnutrition was due mainly to increased availability of the precursor amino acid, and that such alterations in amounts of neurotransmitter amines in the central nervous system might underlie some of the behavioural abnormalities seen in malnourished animals.
与正常喂食的对照动物相比，蛋白质营养不良使豚鼠（增加142%）和大鼠（增加257%）大脑中的组胺含量显著升高。每组动物中，这种生物胺的积累伴随着游离组氨酸脑含量的同等程度增加。得出的结论是，蛋白质营养不良时大脑中组胺含量升高主要是由于前体氨基酸的可用性增加，并且中枢神经系统中神经递质胺量的这种变化可能是营养不良动物出现某些行为异常的原因。
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