Nowak J Z, Maśliński C
Pol J Pharmacol Pharm. 1984 Nov-Dec;36(6):647-51.
Acute treatment of guinea-pigs with ethanol (5 g/kg, directly into the stomach) slightly (by approximately 15%) decreased histamine (HI) content in the hypothalamus, cerebral cortex, rest of the brain and in the whole brain. Prolonged treatment (7-18 days of daily alcohol administration; doses were gradually increasing from 5 to 10 g/kg daily) increased the amine level in the studied tissues by 20-40%. Prolonged treatment of the animals with ethanol plus pyridoxal (Vitamin B6) increased brain HI content to approximately the same extent as did ethanol alone. Both acute and prolonged (18 days) treatment with ethanol did not significantly change activity of the HI synthesizing enzyme, i.e. L-histidine decarboxylase, in the cerebral cortex and in the rest of the brain. The mechanism of ethanol-induced changes in brain HI content is discussed.
用乙醇（5克/千克，直接灌胃）对豚鼠进行急性处理，会使下丘脑、大脑皮层、脑的其他部分以及整个大脑中的组胺（HI）含量略有下降（约15%）。长期处理（每日给予酒精7 - 18天；剂量从每日5克/千克逐渐增加到10克/千克）会使所研究组织中的胺水平提高20 - 40%。用乙醇加吡哆醛（维生素B6）对动物进行长期处理，使脑HI含量增加到与单独使用乙醇时大致相同的程度。乙醇的急性和长期（18天）处理均未显著改变大脑皮层和脑其他部分中HI合成酶即L - 组氨酸脱羧酶的活性。文中讨论了乙醇诱导脑HI含量变化的机制。
