Ruppert B, Blazar B, Medina D, Heppner G
J Immunol. 1979 Jun;122(6):2180-3.
Lymphoid cells isolated form several types of mouse mammary tumors are capable of stimulating tumor cell growth or survival in MCT assays. Lymph node and spleen cells of mice bearing such a tumor are specifically cytotoxic to the tumor cells. Surgical removal of the tumor is followed in 4 to 7 days by the appearance of stimulatory capacity in spleens and lymph nodes. By day 10, cytotoxic cells specific for the sensitizing tumor are again detected. These reach a peak on day 13. By day 17 no reactivity is detectable. The functional distribution of tumor-reactive lymphoid cells is different between tumor masses and peripheral lymphoid organs.
从几种类型的小鼠乳腺肿瘤中分离出的淋巴细胞，在小鼠乳腺肿瘤细胞（MCT）检测中能够刺激肿瘤细胞生长或存活。携带此类肿瘤的小鼠的淋巴结和脾细胞对肿瘤细胞具有特异性细胞毒性。手术切除肿瘤后4至7天，脾脏和淋巴结中会出现刺激能力。到第10天，再次检测到对致敏肿瘤具有特异性的细胞毒性细胞。这些细胞在第13天达到峰值。到第17天，无法检测到反应性。肿瘤反应性淋巴细胞在肿瘤块和外周淋巴器官之间的功能分布有所不同。
