Fisher B, Wolmark N, Saffer E A
J Natl Cancer Inst. 1980 Dec;65(6):1303-5.
The present investigations are a continuation of those indicating that the administration to normal inbred C3HeB/-FeJ mice of syngeneic tumor-sensitized cells or cells from F344 Mai rats (xenogeneic) sensitized to mouse tumor imparted "information" that resulted in the production of tumor-specific cytotoxic cells by recipients. Current findings revealed that normal but not tumor-sensitized spleen cells when transferred to syngeneic tumor-bearing recipients enhanced the cytotoxicity ofrom F344 Mai rats (xenogeneic) sensitized to mouse tumor imparted "information" that resulted in the production of tumor-specific cytotoxic cells by recipients. Current findings revealed that normal but not tumor-sensitized spleen cells when transferred to syngeneic tumor-bearing recipients enhanced the cytotoxicity of lymphoid cells in the recipients. This enhanced cytotoxicity was specific for the immunizing tumor. Inoculation of normal or tumor-sensitized lymph node cells failed to produce such an effect. Our present and previous findings suggested that in the presence of a tumor, uncommitted cells that reside in the spleen and that are available for recruitment and "instruction" may become depleted, whereas no comparable deficit may exist in cells that are capable of information transfer.
目前的研究是先前研究的延续，先前研究表明，给正常近交系C3HeB/-FeJ小鼠注射同基因肿瘤致敏细胞或对小鼠肿瘤致敏的F344 Mai大鼠（异种）的细胞，会传递“信息”，导致受体产生肿瘤特异性细胞毒性细胞。当前研究结果显示，当将正常而非肿瘤致敏的脾细胞转移到同基因荷瘤受体时，会增强受体中来自对小鼠肿瘤致敏的F344 Mai大鼠（异种）的淋巴细胞的细胞毒性。这种增强的细胞毒性对免疫肿瘤具有特异性。接种正常或肿瘤致敏的淋巴结细胞未能产生这种效果。我们目前和先前的研究结果表明，在肿瘤存在的情况下，脾脏中可用于募集和“指导”的未分化细胞可能会被耗尽，而能够进行信息传递的细胞可能不存在类似的缺陷。
