Gose J E, Bach F H
J Exp Med. 1979 May 1;149(5):1254-9. doi: 10.1084/jem.149.5.1254.
Fresh thyroids transplanted to I-region disparate recipients are, in most cases, rejected; in some instances fresh thyroids undergo periods of crisis followed by functional recovery. Cultured thyroids that are taken from donor animals pretreated with lymphocytotoxic drugs, gamma radiation and cultured for 10 d in vitro are not rejected by any normal allogenic recipient. If the recipient is sensitized with lymphoid cells syngeneic with an I-region disparate cultured thyroid donor, the cultured thyroid is rejected if I-A-subregion differences are included. We interpret these data to indicate that there exist I-region encoded perenchymal cell target determinants which are not, by themselves, immunogenic.
新鲜甲状腺移植到I区不相容的受体中，在大多数情况下会被排斥；在某些情况下，新鲜甲状腺会经历危机期，随后功能恢复。取自经淋巴细胞毒性药物预处理、γ射线照射并在体外培养10天的供体动物的培养甲状腺，不会被任何正常同种异体受体排斥。如果受体用与I区不相容的培养甲状腺供体同基因的淋巴细胞致敏，当存在I-A亚区差异时，培养的甲状腺会被排斥。我们解释这些数据表明存在I区编码的实质细胞靶决定簇，其本身不具有免疫原性。
