β-肾上腺素能阻滞剂对正常人和变应性鼻炎患者支气管对乙酰-β-甲基胆碱敏感性的影响。

The effect of beta adrenergic blockade on bronchial sensitivity to acetyl-beta-methacholine in normal and allergic rhinitis subjects.

作者信息

Townley R G, McGeady S, Bewtra A

出版信息

J Allergy Clin Immunol. 1976 Apr;57(4):358-66. doi: 10.1016/0091-6749(76)90093-2.

Abstract

The effect of propranolol inhalation on sensitivity to methacholine inhalation was studied in normal and allergic rhinitis subjects to determine whether beta adrenergic blockade alters sensitivity to mediators in nonasthmatic atopic individuals. A partial beta adrenergic blockade is suggested as being instrumental in asthma. Hay fever patients studied showed similar effects and also developed asthma for the first time.

摘要

在正常人和变应性鼻炎患者中研究了吸入普萘洛尔对吸入乙酰甲胆碱敏感性的影响，以确定β肾上腺素能阻滞是否会改变非哮喘性特应性个体对介质的敏感性。有人提出部分β肾上腺素能阻滞在哮喘中起作用。所研究的花粉症患者显示出类似的效应，并且首次发生了哮喘。