Lindblom U, Verrillo R T
J Neurol Neurosurg Psychiatry. 1979 May;42(5):422-35. doi: 10.1136/jnnp.42.5.422.
Eleven patients with sustained neuralgia, in most cases after traumatic nerve lesion, were subjected to quantitative sensory testing with thermal and non-noxious mechanical stimuli. Measurements were made in the pain area and at a homologous site on the contralateral normal side. All patients were hypoaesthetic with raised thresholds for warm and cold or touch, or both. Thermal pain thresholds were also raised in some patients but lowered in others indicating hypersensitivity of the nociceptor system or dysaesthesia for thermal input. In six patients single mechanical stimuli produced a painful response above the touch detection threshold. Reaction time measurements indicated that this painful response to suprathreshold mechanical pulses was measured by magnitude estimation as a function of stimulus amplitude. The results were fitted by power functions, as in normal skin, but with steeper slopes on the abnormal side. Suprathreshold hyperaesthesia (recruitment) may exist in the presence of normal threshold functioning.
11例患有持续性神经痛的患者，多数病例是在创伤性神经损伤后，接受了热刺激和非伤害性机械刺激的定量感觉测试。在疼痛区域和对侧正常部位的同源部位进行测量。所有患者均存在感觉减退，对温热、冷觉或触觉，或两者的阈值升高。一些患者的热痛阈值也升高，但另一些患者则降低，这表明伤害感受器系统过敏或对热输入感觉异常。在6例患者中，单个机械刺激在触觉检测阈值以上产生疼痛反应。反应时间测量表明，这种对阈上机械脉冲的疼痛反应通过强度估计作为刺激幅度的函数来测量。结果如正常皮肤一样通过幂函数拟合，但异常侧的斜率更陡。在阈值功能正常的情况下，可能存在阈上感觉过敏（募集）。
