Wilkins J, Wehrle P F
J Pediatr. 1979 Jun;94(6):865-9. doi: 10.1016/s0022-3476(79)80203-6.
Quantitative serologic responses following the inoculation of infants less than one year of age with live, further-attenuated measles virus vaccine were compared to those of infants and children inoculated after one year of age. Active/passive immunization resulted in reduced antibody formation in some infants especially those less than 9 months of age. Thirty-seven infants identified as "vaccine failures" following their initial inoculation at less than one year of age were revaccinated after one year of age. Fifty-one percent had no detectable HI antibody by eight months postrevaccination, contrasted to 6.8% of the vaccinees with no detectable HI antibody following one inoculation after one year of age; 49% responded optimally to revaccination. In face of an observed altered response in many infants less than one year of age, it would appear prudent to withhold vaccine in this age group until the consequences of such an approach are better defined.
将小于1岁的婴儿接种进一步减毒的麻疹活病毒疫苗后的定量血清学反应，与1岁后接种疫苗的婴儿和儿童的反应进行了比较。主动/被动免疫导致一些婴儿，尤其是9个月以下的婴儿抗体形成减少。37名在1岁以下初次接种疫苗后被确定为“疫苗接种失败”的婴儿在1岁后重新接种疫苗。重新接种疫苗后8个月，51%的婴儿检测不到血凝抑制（HI）抗体，相比之下，1岁后接种一次疫苗后检测不到HI抗体的接种者为6.8%；49%的婴儿对重新接种疫苗反应良好。鉴于观察到许多小于1岁的婴儿反应发生改变，在该年龄组中暂不接种疫苗似乎是谨慎的做法，直到这种做法的后果得到更明确的界定。
