Wilkins J, Wehrle P F
Am J Dis Child. 1978 Feb;132(2):164-6. doi: 10.1001/archpedi.1978.02120270062013.
The hemagglutination inhibition (HI) serologic responses of 851 measles-susceptible infants and children to the live, further-attenuated measles virus vaccine were evaluated over a ten-year period. The response by age at 23-day intervals was determined. Infants inoculated at 12 through 14 months of age demonstrated seroconversion rates by HI assay comparable to those in infants and children inoculated at 15 months of age or older. This finding does not support the recent recommendation that routine active immunization with measles vaccine should be postponed until 15 months of age. We emphasize the possible consequence of electively leaving infants 12 throught 14 months of age vulnerable to measles because of the current endemicity of this disease in the United States. We also present evidence for the reinstatement of infants 12 through 14 months of age into routine measles immunization programs and for the need to further evaluate the causes for vaccine failure in vaccines after the loss of maternal antibody.
在十年期间，对851名易感麻疹的婴幼儿针对进一步减毒的麻疹活病毒疫苗的血凝抑制（HI）血清学反应进行了评估。每隔23天测定一次不同年龄的反应情况。12至14月龄接种疫苗的婴儿通过HI检测显示的血清转化率与15月龄及以上接种疫苗的婴幼儿相当。这一发现不支持最近关于将麻疹疫苗常规主动免疫推迟至15月龄的建议。鉴于美国目前麻疹的流行情况，我们强调，选择让12至14月龄的婴儿易患麻疹可能产生的后果。我们还提供了证据，支持将12至14月龄的婴儿重新纳入常规麻疹免疫计划，并支持进一步评估母体抗体消失后疫苗接种失败原因的必要性。
