Matustik M C, Carpentieri U, Corn C, Meyer W J
J Pediatr. 1979 Aug;95(2):206-9. doi: 10.1016/s0022-3476(79)80652-6.
Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities and aldosterone secretion rates. The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.
对14名年龄在6至20岁的镰状细胞贫血患者进行了研究，观察他们在摄入高钠和低钠饮食时的情况。虽然没有患者出现钠的尿排泄过多，但大多数患者的血浆肾素活性和醛固酮分泌率升高。10岁以上患者的血浆肾素活性更高；接受高钠饮食的患者的醛固酮分泌率随年龄增加。镰状细胞贫血患者似乎在两次危象之间对尿钠丢失进行了代偿。这种丢失的机制可能是远端小管或髓袢功能存在缺陷。
