Matustik M C, Chausmer A B, Meyer W J
J Am Coll Nutr. 1982;1(4):331-6. doi: 10.1080/07315724.1982.10719003.
Urinary zinc excretion is known to be elevated in subjects with sickle cell anemia. Sodium intake has been suggested to influence zinc excretion in normal subjects. In order to assess the effect of sodium on zinc excretion in subjects with sickle cell anemia, urinary zinc excretion was measured in thirteen children and adolescents with sickle cell anemia on both a high (140 mEq/day) and low (20 mEq/day) sodium intake. Urinary zinc excretion was elevated on both diets. The mean urinary zinc excretion on the high sodium diet (775 +/- 238 micrograms/24 h) was significantly lower (P less than .005) than that on the low sodium diet (947 +/- 344 micrograms/24 h). The zinc excretion did not correlate with calcium or magnesium excretion or aldosterone secretion rates or plasma renin activity. Although elevated, the urinary zinc excretion in patients with sickle cell anemia is still significantly lowered by increasing sodium intake.
已知镰状细胞贫血患者的尿锌排泄量会升高。有人提出钠摄入量会影响正常受试者的锌排泄。为了评估钠对镰状细胞贫血患者锌排泄的影响，对13名患有镰状细胞贫血的儿童和青少年在高钠（140毫当量/天）和低钠（20毫当量/天）摄入情况下的尿锌排泄量进行了测量。两种饮食情况下尿锌排泄量均升高。高钠饮食时的平均尿锌排泄量（775±238微克/24小时）显著低于低钠饮食时的（947±344微克/24小时）（P＜0.005）。锌排泄与钙或镁排泄、醛固酮分泌率或血浆肾素活性均无相关性。尽管镰状细胞贫血患者的尿锌排泄量升高，但增加钠摄入量仍可使其显著降低。
