Weintraub M, Karch F E, Morgan J P, Trabert N, Sorensen A, Becker L A, Lasagna L
JAMA. 1979 Aug 3;242(5):445-8.
We examined digoxin-prescribing in 47,000 prescriptions written predominantly by physicians in a large family medicine practice. Two hundred fifty-four patients received 511 digoxin prescriptions. Dose adjustments for age (16% decrease in patients older than 64 years), for renal disease (33% decrease), and for atrial fibrillation (39% increase) followed good prescribing practices. Appropriately lower loading doses were used for digitalization. However, despite continuing concern over the bioavailability of generic digoxin tablets, less than 40% of digoxin prescriptions in this study were written for the innovator's brand-name product (Lanoxin).
我们研究了主要由一家大型家庭医疗诊所的医生开具的47000份处方中的地高辛处方情况。254名患者共收到511份地高辛处方。针对年龄（64岁以上患者剂量降低16%）、肾脏疾病（剂量降低33%）和心房颤动（剂量增加39%）进行的剂量调整遵循了良好的处方规范。在进行洋地黄化时使用了适当较低的负荷剂量。然而，尽管人们一直对通用型地高辛片剂的生物利用度存在担忧，但在本研究中，开具地高辛处方时选用原研品牌产品（Lanoxin）的比例不到40%。
