Greenwood D, Kawada Y, O'Grady F
Infection. 1980;Suppl 1:35-8. doi: 10.1007/BF01644933.
Experimental and clinical data from which dosage regimens can be rationally deduced are generally lacking. As an approach to this problem, an in vitro model of the urinary bladder has been constructed in which the conditions of exposure of bacteria to antibacterial drugs which exist in the treatment of cystitis are simulated. Results obtained so far correlate well with such clinical information as we possess and have helped to define more accurately the conditions which govern successful therapy of urinary infection. The most recent data suggest that much lower doses of some beta-lactam antibiotics than have been contemplated hitherto may be effective in the treatment of uncomplicated cystitis.
通常缺乏能合理推导给药方案的实验和临床数据。作为解决这一问题的方法，已构建了膀胱体外模型，该模型模拟了膀胱炎治疗中细菌接触抗菌药物的条件。目前获得的结果与我们所拥有的此类临床信息相关性良好，并有助于更准确地确定成功治疗泌尿系统感染的条件。最新数据表明，一些β-内酰胺类抗生素的剂量可能比迄今设想的要低得多，对治疗单纯性膀胱炎有效。
