线粒体结构与功能的机电化学模型
Electromechanochemical model of mitochondrial structure and function.
作者信息
Green D E, Ji S
出版信息
Proc Natl Acad Sci U S A. 1972 Mar;69(3):726-9. doi: 10.1073/pnas.69.3.726.
Abstract
A NEW MODEL OF MITOCHONDRIAL STRUCTURE AND FUNCTION IS PROPOSED ON THE BASIS OF FOUR FUNDAMENTAL ASSUMPTIONS
(a) electrons and protons are separated in the electron transfer complexes; (b) the ATPase undergoes conformational state-transitions induced by an electric field; (c) energy is transferred by an electric field effect; and (d) a conformationally strained protein system can be relaxed via a bond-forming chemical reaction. The model can explain all of the mitochondrial coupled processes and, in addition, it provides a reasonable rationalization of the correlation between mitochondrial structure and function.
摘要
基于四个基本假设提出了一种线粒体结构与功能的新模型
(a)电子和质子在电子传递复合物中分离；(b)ATP酶经历由电场诱导的构象状态转变；(c)能量通过电场效应传递；(d)构象应变的蛋白质系统可通过形成键的化学反应得以松弛。该模型能够解释所有线粒体偶联过程，此外，还为线粒体结构与功能之间的相关性提供了合理的阐释。
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