Gadaleta M N, Giuffrida A M, Renis M, Serra I, Del Prete G, Geremia E, Saccone C
Neurochem Res. 1979 Feb;4(1):25-35. doi: 10.1007/BF00963829.
DNA, RNA, and protein synthesis in mitochondria isolated from cerebral hemispheres, brain stem, and cerebellum of 10- and 30-day-old rats was measured. Synthesis of different macromolecules was affected by the respective mitochondrial specific inhibitors, showing a good level of purity of mitochondrial preparations. DNA and protein synthesis in 10-day-old rats was about 70% higher than in 30-day-old animals. In contrast, RNA synthesis did not decrease with age in all the regions examined.
