环己酰亚胺处理的小鼠中记忆的可变衰退及其恢复
Variable decay of memory and its recovery in cycloheximide-treated mice.
作者信息
Squire L R, Barondes S H
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1416-20. doi: 10.1073/pnas.69.6.1416.
Abstract
Mice were trained in an automated visual-discrimination task. When injected with cycloheximide before training, mice showed: (a) some impairment of memory within minutes after the beginning of training, (b) gradual development of total amnesia in less than 3 hr or in more than 6 hr after training, depending on the extent of training, and (c) spontaneous recovery of memory within 3 days after training. The results are consistent with the operation of three processes of memory storage: (i) a short-term process that is independent of protein synthesis, (ii) a long-term that is dependent on protein synthesis, and (iii) a slow-developing memory storage that becomes apparent during the days after training.
摘要
小鼠接受了一项自动化视觉辨别任务的训练。在训练前注射环己酰亚胺后，小鼠表现出：(a) 训练开始后几分钟内记忆出现一些损伤；(b) 根据训练程度不同，在训练后不到3小时或超过6小时逐渐发展为完全失忆；(c) 训练后3天内记忆自发恢复。这些结果与记忆存储的三个过程的运作一致：(i) 一个独立于蛋白质合成的短期过程；(ii) 一个依赖于蛋白质合成的长期过程；(iii) 一个在训练后数天内变得明显的缓慢发展的记忆存储过程。
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