三种移植瘤免疫扰动期间的细胞增殖
Cell proliferation during immunological perturbation in three transplanted tumours.
作者信息
Janik P, Steel G G
出版信息
Br J Cancer. 1972 Apr;26(2):108-14. doi: 10.1038/bjc.1972.16.
Abstract
The cell population kinetics of 3 transplantable tumours has been studied under circumstances in which the tumour growth rate was modified by a disturbance of the immunological status of the host. In 2 cases a complete arrest of growth was achieved but in spite of this there was a barely significant change in the median intermitotic time of proliferating cells. The data indicate that growth retardation was associated with a reduction in the proportion of actively proliferating cells and the rate of cell production, with or without an increase in the absolute rate of cell loss.
摘要
在宿主免疫状态受到干扰从而改变肿瘤生长速率的情况下，对3种可移植肿瘤的细胞群体动力学进行了研究。在2个病例中实现了生长的完全停滞，但尽管如此，增殖细胞的中位分裂间期几乎没有显著变化。数据表明，生长迟缓与活跃增殖细胞比例和细胞产生速率的降低有关，无论细胞丢失的绝对速率是否增加。
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