美沙酮血浆水平：由组织中的药物储备维持。
Methadone plasma level: sustained by a reservoir of drug in tissue.
作者信息
Dole V P, Kreek M J
出版信息
Proc Natl Acad Sci U S A. 1973 Jan;70(1):10. doi: 10.1073/pnas.70.1.10.
Abstract
Binding of methadone in body tissues limits the rise in plasma concentration and prolongs the pharmacological action in patients receiving a daily maintenance dose. An opiate with equal intrinsic activity but greater binding affinity would, therefore, be a better drug than methadone for maintenance treatment; it would be safer when taken in a single dose and longer in its duration of action when taken on a regular schedule.
摘要
美沙酮与人体组织的结合限制了血浆浓度的升高，并延长了接受每日维持剂量患者的药理作用。因此，一种具有同等内在活性但结合亲和力更高的阿片类药物，作为维持治疗用药会比美沙酮更好；单次服用时会更安全，按常规服用时作用持续时间会更长。
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本文引用的文献
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Quantitative determination of methadone concentrations in human blood, plasma and urine by gas chromatography.气相色谱法定量测定人血液、血浆和尿液中的美沙酮浓度。
Res Commun Chem Pathol Pharmacol. 1972 May;3(3):467-78.
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A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine.一种用于定量测定人血浆和尿液中美沙酮的气-液色谱法。
J Chromatogr. 1972 Feb 23;65(2):361-9. doi: 10.1016/s0021-9673(00)92558-5.
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Narcotic blockade.麻醉性阻滞
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