消旋美沙酮在体外治疗胶质母细胞瘤的疗效
Efficacy of D,L-methadone in the treatment of glioblastoma in vitro.
作者信息
Brawanski Konstantin, Brockhoff Gero, Hau Peter, Vollmann-Zwerenz Arabel, Freyschlag Christian, Lohmeier Annette, Riemenschneider Markus J, Thomé Claudius, Brawanski Alexander, Proescholdt Martin A
机构信息
Department of Neurosurgery, University Hospital Innsbruck, Innsbruck, Austria.
Department of Gynecology & Obstetrics, University Hospital Regensburg, Regensburg, Germany.
出版信息
CNS Oncol. 2018 Jul 1;7(3):CNS18. doi: 10.2217/cns-2018-0006. Epub 2018 Jun 19.
AIM
Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM).
METHODS
We analyzed the μ-opioid receptor expression in a set of GBM cell lines and investigated the efficacy of D,L-methadone alone and in combination with temozolomide (TMZ). Results & conclusion: Expression of the μ-opioid receptor was similar in the tested cell lines. High concentrations of D,L-methadone induced apoptosis in all cell lines and showed treatment interaction with TMZ. However, in lower dosages, reflecting clinically attainable concentrations, D,L-methadone alone showed no efficacy, and induced even higher proliferation in one specific cell line. Also, no interaction with TMZ was observed. These results suggest caution to the premature use of D,L-methadone in the treatment of GBM patients.
目的
最近，消旋美沙酮已被提出作为胶质母细胞瘤（GBM）的辅助治疗方法。
方法
我们分析了一组GBM细胞系中μ-阿片受体的表达情况，并研究了消旋美沙酮单独使用以及与替莫唑胺（TMZ）联合使用的疗效。结果与结论：受试细胞系中μ-阿片受体的表达相似。高浓度的消旋美沙酮可诱导所有细胞系凋亡，并显示出与TMZ的治疗相互作用。然而，在反映临床可达到浓度的较低剂量下，消旋美沙酮单独使用无疗效，甚至在一个特定细胞系中诱导了更高的增殖。此外，未观察到与TMZ的相互作用。这些结果提示在GBM患者治疗中过早使用消旋美沙酮需谨慎。
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