Walton R G, Thornton T L, Wahl G F
Int J Addict. 1978 Jul;13(5):689-94. doi: 10.3109/10826087809039295.
Serial serum methadone levels were obtained in two patients who were experiencing significant difficulties (including subjective and objective evidence of the opiate withdrawal syndrome) while on methadone maintenance. A precipitous drop in blood levels of methadone was recorded 2 to 6 hours after ingestion. It was during this same time period that withdrawal symptoms were most severe. When methadone was administered on a divided dosage regimen, there was a dramatic clinical improvement in both patients and a marked flattening of the curve of serum methadone levels. This pilot study suggests that the current practice of administering methadone as a single daily dose to all patients needs reconsideration; serial serum methadone levels may be helpful in determining which patients do better on a divided dosage regimen.
对两名正在接受美沙酮维持治疗但遇到严重问题（包括阿片戒断综合征的主观和客观证据）的患者进行了系列血清美沙酮水平检测。在摄入美沙酮后2至6小时记录到美沙酮血药水平急剧下降。正是在同一时间段内，戒断症状最为严重。当采用分次给药方案给予美沙酮时，两名患者的临床症状均有显著改善，血清美沙酮水平曲线明显变平。这项初步研究表明，目前对所有患者每日单次给予美沙酮的做法需要重新考虑；系列血清美沙酮水平可能有助于确定哪些患者采用分次给药方案效果更好。
