霍奇金病。250例临床病理研究及5年随访
Hodgkin's disease. A clinico-pathological study of 250 cases with a 5-year follow-up.
作者信息
Newton K A, Mackenzie D H, Spittle M F, Mikolajczuk A
出版信息
Br J Cancer. 1973 Jan;27(1):80-91. doi: 10.1038/bjc.1973.10.
Two hundred and fifty cases of histologically proven Hodgkin's disease have been reviewed. These cases were classified according to the Rye Conference histological classification (Lukes et al., 1966a) and according to the Cross classification (Cross, 1969). Overall, both classifications were reasonably effective in predicting prognosis but that of Cross with its seven sub-groups proved more difficult to use than the simpler Rye classification. In all cases the follow-up period exceeded 5 years. A study was made of the influence of clinical symptoms on survival with particular reference to night sweats, fever, pruritus, anorexia, lassitude, weight loss, haematological abnormalities and splenic enlargement. The presence of these abnormalities adversely affected prognosis. The spread of the disease from one group of nodes to the next was also documented. Considering all cases the 5-year survival was 54%. The 5-year survivals according to histological type were: lymphocytic predominance 69%, nodular sclerosis 57%, mixed cellularity 41%, lymphocytic depletion 40%. The 10-year survival was 23% which, when corrected by the actuarial method (Berkson and Gage, 1950), rose to 36%. The importance of symptomatology as well as histological grading in the prognosis of Hodgkin's disease is confirmed.
对250例经组织学证实的霍奇金病病例进行了回顾性研究。这些病例根据Rye会议组织学分类法（Lukes等人，1966年a）以及Cross分类法（Cross，1969年）进行分类。总体而言，两种分类法在预测预后方面都相当有效，但Cross分类法及其七个亚组的分类比更简单的Rye分类法更难使用。所有病例的随访期均超过5年。研究了临床症状对生存的影响，特别提及盗汗、发热、瘙痒、厌食、倦怠、体重减轻、血液学异常和脾肿大。这些异常的存在对预后产生不利影响。还记录了疾病从一组淋巴结扩散到另一组淋巴结的情况。考虑所有病例，5年生存率为54%。根据组织学类型的5年生存率分别为：淋巴细胞为主型69%，结节硬化型57%，混合细胞型41%，淋巴细胞消减型40%。10年生存率为23%，经精算方法校正（Berkson和Gage，1950年）后升至36%。症状学以及组织学分级在霍奇金病预后中的重要性得到了证实。
Zotero 插件