人体中由14C-L-组氨酸生成组胺的过程。

Histamine formation from 14 C-L-histidine in man.

Berg B, Granerus G, Johansson M B, Westling H, White T

Br J Pharmacol. 1972 Oct;46(2):270-80. doi: 10.1111/j.1476-5381.1972.tb06872.x.

Abstract

(14)C-L-histidine was given i.v. to one normal subject and two patients with chronic myelocytic leukaemia. Urinary excretion of histamine and two of its metabolites methylhistamine and methylimidazoleacetic acid, total as well as (14)C-labelled, was measured, as well as blood (14)C-histamine. In addition the total urinary and pulmonary elimination of (14)C was followed.2. Total (14)C elimination was high during the first days, then declined slowly except for a plateau at the 10th-14th day in the two patients. There was a measurable elimination even after some months.3. (14)C-histamine appeared in the blood of the leukaemic patient, whereas in the normal subjects the values were hardly measurable.4. The leukaemic patients excreted much more of the two (14)C-labelled histamine metabolites than the normal subject. The difference in excretion of the (14)C-labelled metabolites was largest around the 12th day after the infusion of (14)C-L-histidine.5. The results indicate that the leukaemic patients formed at least 20 times more histamine daily than the normal subject.

摘要

给一名正常受试者和两名慢性粒细胞白血病患者静脉注射了¹⁴C-L-组氨酸。测量了组胺及其两种代谢产物甲基组胺和甲基咪唑乙酸的尿排泄量，包括总量以及¹⁴C标记的量，同时还测量了血液中¹⁴C-组胺的含量。此外，还跟踪了¹⁴C在尿液和肺部的总排泄情况。
在最初几天，¹⁴C的总排泄量很高，之后除了两名患者在第10至14天出现一个平台期外，排泄量缓慢下降。即使在几个月后仍有可测量的排泄。
¹⁴C-组胺出现在白血病患者的血液中，而在正常受试者中，其值几乎无法测量。
白血病患者排泄的两种¹⁴C标记的组胺代谢产物比正常受试者多得多。在注射¹⁴C-L-组氨酸后约第12天，¹⁴C标记代谢产物的排泄差异最大。
结果表明，白血病患者每天形成的组胺至少是正常受试者的20倍。