Ganzinger U, Moser K
Recent Results Cancer Res. 1979;67:50-5. doi: 10.1007/978-3-642-81320-7_8.
Clinical evaluation of serum sialyl transferase as a diagnostic tool in malignant disease has shown that there is a strong correlation between enzyme activity and extent of tumor tissue. Thus, patients with large tumor masses show higher enzyme activity than patients with small tumors or in remission. Furthermore, the surgical removal of tumor tissue results in a decrease of enzyme activity to the normal range. The values remain low until metastases recur; this is connected with a new increase in enzyme activity. It has also been shown that successful chemotherapy corresponding to tumor reduction is reflected in lower values. We are thus led to believe that sialyl transferase is a relevant diagnostic blood parameter in the follow-up of cancer patients.
血清唾液酸转移酶作为恶性疾病诊断工具的临床评估表明，酶活性与肿瘤组织范围之间存在密切关联。因此，肿瘤肿块大的患者比肿瘤小或处于缓解期的患者酶活性更高。此外，手术切除肿瘤组织会导致酶活性降至正常范围。在转移复发之前，该值一直保持较低水平；这与酶活性的再次升高有关。研究还表明，与肿瘤缩小相应的成功化疗表现为较低的值。因此，我们认为唾液酸转移酶是癌症患者随访中的一个相关诊断血液参数。
