Vanderschueren R G, Laros C D, Swierenga J
Respiration. 1979;37(6):318-27. doi: 10.1159/000194044.
Study of the influence of different modes of administration of 200 microgram of fenoterol showed that in a selected group of patients, two thirds of the maximal obtainable decrease in airway resistance could be achieved within 3 min of local application of 200 microgram fenoterol onto the nasal mucosa, without inhalation into the lower airways. Aspects of the potential pathways by which inhaled substances reach their receptor or target sites are discussed.
对200微克非诺特罗不同给药方式影响的研究表明,在一组选定的患者中,将200微克非诺特罗局部应用于鼻黏膜3分钟内,无需吸入下呼吸道,即可实现气道阻力最大可降低值的三分之二。文中讨论了吸入性物质到达其受体或靶位点的潜在途径。