Fishman J, Fukushima D K, O'Connor J, Lynch H T
Science. 1979 Jun 8;204(4397):1089-91. doi: 10.1126/science.451553.
Daily (12-hour) urine collections taken throughout the menstrual cycle were obtained from 30 young women who by genetic analysis were at risk for familial breast cancer, and from 30 control women carefully matched for age, height, and reproductive history. Steroids in the urine were extracted by glucuronidase hydrolysis, and the primary glucocorticoid, androgen, and estrogen hormones and their metabolites were measured by radioimmunoassay. Highly significant differences were observed only in the case of estrone and estradiol, with the high-risk subjects exhibiting lower values that the controls. This endocrine abnormality in young women at risk for breast cancer may be a potential discriminant for identifying women at risk for the disease in the population at large.
在整个月经周期中，每天（12小时）收集30名通过基因分析有患家族性乳腺癌风险的年轻女性以及30名年龄、身高和生殖史经过精心匹配的对照女性的尿液。尿液中的类固醇通过葡萄糖醛酸酶水解提取，主要的糖皮质激素、雄激素、雌激素及其代谢产物通过放射免疫测定法进行测量。仅在雌酮和雌二醇的情况下观察到高度显著差异，高危受试者的值低于对照组。乳腺癌高危年轻女性的这种内分泌异常可能是在普通人群中识别该疾病高危女性的潜在判别指标。
