Fishman J, Bradlow H L, Fukushima D K, O'Connor J, Rosenfeld R S, Graepel G J, Elston R, Lynch H
Cancer Res. 1983 Apr;43(4):1884-90.
The present study was designed to establish whether women with a family history of breast cancer exhibit endocrine abnormalities which could be responsible for their increased risk for the disease. Plasma hormone levels were measured every second day throughout the menstrual cycle in 30 women at risk for familial breast cancer and in an equal number of matched controls. Thirteen of the 14 substances measured exhibited no differences between the two populations, but plasma androsterone sulfate was significantly lower in the high-risk subjects. Thirteen urinary hormones were measured every day throughout the cycle with only the mean estrone and estradiol glucuronide but not estriol glucuronide content being significantly lower in the high-risk subjects. A compensatory increase in the urinary estrogen sulfates was observed. Daily analysis of these differences showed that they were most pronounced in thry day throughout the cycle with only the mean estrone and estradiol glucuronide but not estriol glucuronide content being significantly lower in the high-risk subjects. A compensatory increase in the urinary estrogen sulfates was observed. Daily analysis of these differences showed that they were most pronounced in thry day throughout the cycle with only the mean estrone and estradiol glucuronide but not estriol glucuronide content being significantly lower in the high-risk subjects. A compensatory increase in the urinary estrogen sulfates was observed. Daily analysis of these differences showed that they were most pronounced in the periovulatory period of the cycle. These results suggest that the genetic risk for breast cancer is associated with an abnormality in estrogen conjugation at a specific time of the ovulatory cycle.
本研究旨在确定有乳腺癌家族史的女性是否存在内分泌异常，这种异常可能是她们患该疾病风险增加的原因。在整个月经周期中，每隔一天测量30名有家族性乳腺癌风险的女性以及同等数量匹配对照者的血浆激素水平。所测量的14种物质中有13种在两组人群中无差异，但高危受试者的血浆硫酸雄酮显著较低。在整个周期中每天测量13种尿激素，只有高危受试者的尿雌酮和雌二醇葡糖苷酸平均含量显著较低，而尿雌三醇葡糖苷酸含量无显著差异。观察到尿雌激素硫酸盐有代偿性增加。对这些差异的每日分析表明，它们在整个周期的第三天最为明显，只有高危受试者的尿雌酮和雌二醇葡糖苷酸平均含量显著较低，而尿雌三醇葡糖苷酸含量无显著差异。观察到尿雌激素硫酸盐有代偿性增加。对这些差异的每日分析表明，它们在整个周期的第三天最为明显，只有高危受试者的尿雌酮和雌二醇葡糖苷酸平均含量显著较低，而尿雌三醇葡糖苷酸含量无显著差异。观察到尿雌激素硫酸盐有代偿性增加。对这些差异的每日分析表明，它们在周期的排卵期最为明显。这些结果表明，乳腺癌的遗传风险与排卵周期特定时间的雌激素结合异常有关。
