Voors A W, Berenson G S, Dalferes E R, Webber L S, Shuler S E
Science. 1979 Jun 8;204(4397):1091-4. doi: 10.1126/science.451554.
Children from an entire biracial geographical population were examined for blood pressure. A sample of 278 children, stratified by diastolic blood pressure, was reexamined 1 to 2 years later. Dopamine beta-hydroxylase, renin activity, and resting heart rate were observed in black and white children. In the group with high blood pressure, whites had higher heart rates and greater renin activity than blacks. Dopamine beta-hydroxylase concentrations in blacks were lower than in whites over the entire spectrum of blood pressure levels. High blood pressure seems to have a different metabolic background in the two races which may influence the early natural history of essential hypertension. Therefore, the rationale of prevention, and possibly treatment, of early hypertension in blacks and whites may differ.
对来自整个混血地理区域的儿童进行了血压检查。从278名儿童中抽取了一个按舒张压分层的样本，在1至2年后进行了重新检查。观察了黑人和白人儿童的多巴胺β-羟化酶、肾素活性和静息心率。在高血压组中，白人的心率和肾素活性高于黑人。在整个血压水平范围内，黑人的多巴胺β-羟化酶浓度低于白人。高血压在两个种族中似乎有不同的代谢背景，这可能会影响原发性高血压的早期自然病程。因此，黑人和白人早期高血压的预防原理以及可能的治疗方法可能不同。
