Brooks J E, Bowerman A M
J Hyg (Lond). 1973 Jun;71(2):217-22. doi: 10.1017/s0022172400022683.
Wild Norway rats (Rattus norvegicus) from several habitats were tested for their susceptibility and resistance to warfarin. Animals were fed 0.005% warfarin in ground oatmeal for periods varying from 1 to 12 days. Rats having no prior exposure to anticoagulants were shown to be susceptible, none having survived a 6-day feeding period. Resistant rats were found on two farms where anticoagulant materials had been used intensively for about 20 years.
对来自多个栖息地的野生挪威大鼠(褐家鼠)进行了对华法林的易感性和抗性测试。给动物喂食含0.005%华法林的燕麦粉,喂食期从1天到12天不等。此前未接触过抗凝血剂的大鼠表现出易感性,在6天的喂食期后无一存活。在两个农场发现了抗性大鼠大鼠,这两个农场大量使用抗凝血剂已有约20年。