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纽约野生褐家鼠的抗凝血剂抗性

Anticoagulant resistance in wild Norway rats in New York.

作者信息

Brooks J E, Bowerman A M

出版信息

J Hyg (Lond). 1973 Jun;71(2):217-22. doi: 10.1017/s0022172400022683.

Abstract

Wild Norway rats (Rattus norvegicus) from several habitats were tested for their susceptibility and resistance to warfarin. Animals were fed 0.005% warfarin in ground oatmeal for periods varying from 1 to 12 days. Rats having no prior exposure to anticoagulants were shown to be susceptible, none having survived a 6-day feeding period. Resistant rats were found on two farms where anticoagulant materials had been used intensively for about 20 years.

摘要

对来自多个栖息地的野生挪威大鼠(褐家鼠)进行了对华法林的易感性和抗性测试。给动物喂食含0.005%华法林的燕麦粉,喂食期从1天到12天不等。此前未接触过抗凝血剂的大鼠表现出易感性,在6天的喂食期后无一存活。在两个农场发现了抗性大鼠大鼠,这两个农场大量使用抗凝血剂已有约20年。

相似文献

1
Anticoagulant resistance in wild Norway rats in New York.纽约野生褐家鼠的抗凝血剂抗性
J Hyg (Lond). 1973 Jun;71(2):217-22. doi: 10.1017/s0022172400022683.

本文引用的文献

1
RESISTANCE TO WARFARIN IN THE COMMON RAT.
Nature. 1964 Aug 15;203:778. doi: 10.1038/203778a0.
2
4
Warfarin-resistance in the Netherlands.荷兰的华法林抵抗情况。
Schriftenr Ver Wasser Boden Lufthyg. 1969;32:39-47.
5
Resistance to anticoagulants in Denmark.丹麦对抗凝剂的耐药性。
Schriftenr Ver Wasser Boden Lufthyg. 1969;32:27-38.
6
The warfarin resistance problem in England and Wales.
Schriftenr Ver Wasser Boden Lufthyg. 1969;32:19-25.

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