噬菌体Mu DNA中倒位环的遗传图谱
Genetic mapping of the inversion loop in bacteriophage Mu DNA.
作者信息
Daniell E, Boram W, Abelson J
出版信息
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2153-6. doi: 10.1073/pnas.70.7.2153.
Abstract
An inversion loop seen in heteroduplex mapping of the DNA of mature Mu phage induced from a lysogen is observed also in defective lambda phage carrying one end of Mu. 14% of the DNA of Mu, including this region, designated the G loop, is shown to be to the right of all known genes in the prophage map. The inhomogeneous ends of Mu are observed as a separate phenomenon and appear in all mutants investigated. The recA and recBC functions of the host are not needed for the inversion responsible for the G loop to take place. Deletions of Mu DNA in the G-loop region have been isolated and are under study.
摘要
在从溶源菌诱导产生的成熟Mu噬菌体DNA的异源双链图谱中观察到的倒位环，在携带Mu一端的缺陷型λ噬菌体中也能观察到。Mu的14%的DNA，包括这个被称为G环的区域，在原噬菌体图谱中显示位于所有已知基因的右侧。Mu的不均匀末端作为一种单独的现象被观察到，并且出现在所有研究的突变体中。导致G环出现的倒位不需要宿主的recA和recBC功能。已经分离出G环区域的Mu DNA缺失，并正在进行研究。
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本文引用的文献
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J Mol Biol. 1971 Nov 28;62(1):171-8. doi: 10.1016/0022-2836(71)90137-9.
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Virology. 1973 Jan;51(1):237-9. doi: 10.1016/0042-6822(73)90385-1.
3
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Deletion mutants of bacteriophage lambda. I. Isolation and initial characterization.噬菌体λ的缺失突变体。I. 分离与初步表征。
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