Shin C S, Chaudhry A G, Elizalde A, Sittisuntorn O
Surg Gynecol Obstet. 1979 Jun;148(6):913-6.
In 12 mongrel dogs, the comparative effectiveness of systemic versus regional heparinization was studied after injecting 100 units per kilogram of heparin into a systemic vein or regionally into an artery. Activated plasma thromboplastin time was used to monitor the heparin activity, and the coagulability of blood in the general circulation was compared with the coagulability of blood in the excluded circulation distal to the vascular clamps. Both methods of heparinization were found to be equally effective. Heparin injected regionally rapidly achieves a uniform distribution in the excluded, as well as the general, circulation and, as such, cannot be called regional. There was no difference in coagulability of blood in the general circulation compared with the blood in the excluded circulation. Results of this study suggest that regional heparinization is, in fact, systemic heparinization.
在12只杂种狗中，通过向体静脉或动脉局部注射每千克100单位肝素，研究了全身肝素化与局部肝素化的相对有效性。使用活化部分凝血活酶时间监测肝素活性，并将体循环中血液的凝固性与血管夹远端排除循环中血液的凝固性进行比较。发现两种肝素化方法同样有效。局部注射的肝素在排除循环以及体循环中迅速达到均匀分布，因此不能称之为局部肝素化。体循环中血液的凝固性与排除循环中血液的凝固性没有差异。本研究结果表明，局部肝素化实际上就是全身肝素化。
