Belousov A E, Bovtunov A Z, Ivanov I V
Vestn Khir Im I I Grek. 1984 Apr;132(4):54-7.
Experiments on 32 dogs have shown that the greatest effect of medication on particular anatomical zone may be achieved by maximum approximation of the level of catheterization of the feeding artery to the zone. It may be achieved by the microsurgery technique. Permanent intraarterial administration of solutions of heparin in experiments and clinic is thought to provide a sufficient effect of the regional anticoagulating therapy, by creating a high concentration of the drug in the zone of microanastomosis with its low concentration in the general blood flow.
对32只狗进行的实验表明，通过使供血动脉插管水平尽可能接近特定解剖区域，可实现药物对该区域的最大作用。这可通过显微外科技术来实现。在实验和临床中，肝素溶液的永久性动脉内给药被认为可通过在微吻合区域产生高浓度药物而在全身血流中保持低浓度，从而提供足够的局部抗凝治疗效果。
