Herbert J L, Fabre M, Auzépy P, Paillas J
Toxicol Eur Res. 1978;1(5):2890-94.
Acute intoxication by diethylene glycol (LD 50) in male rats is associated with a severe metabolic acidosis which is significantly decreased by intraperitoneal (IP) hydration or IP alkalinization and eliminated by IP ethanol. Tubular necrosis and deposit of calcium oxalate crkystals constitute the histological renal lesions in 50% of rats given diethylene glycol with or without IP hydration. Groups with massive IP alkalinization and/or IP ethanol do not present any renal lesion. It could be inferred that diethylene glycol has the same metabolic pathway as ethylene glycol and the treatment of acute intoxication by diethylene glycol should be the same as that of acute poisoning by ethylene glycol.
雄性大鼠经二甘醇急性中毒（半数致死量）会引发严重的代谢性酸中毒，腹腔内补液或腹腔内碱化可使其显著减轻，腹腔内注射乙醇则可消除该症状。给予二甘醇的大鼠中，无论是否进行腹腔内补液，50%的大鼠组织学肾脏损伤表现为肾小管坏死和草酸钙结晶沉积。进行大量腹腔内碱化和/或腹腔内注射乙醇的组未出现任何肾脏损伤。可以推断，二甘醇与乙二醇具有相同的代谢途径，二甘醇急性中毒的治疗方法应与乙二醇急性中毒相同。
