Durand A, Auzépy P, Hébert J L, Trieu T C
Eur J Intensive Care Med. 1976 Nov;2(3):143-6. doi: 10.1007/BF00579697.
Acute intoxication by diethylene glycol (LD 50) in male rats is associated with a considerable urinary excretion of oxalate, which is significantly decreased by alkalinisatin and/or intraperitoneal injection of ethanol with hydration. Mortality during the five days following intoxication is significantly decreased by major hydration only or together with pyridoxine administration, but is cancelled by major hydration together with alkalinisation or intraperitoneal administration of ethanol, plus hydration, with or without alkalinisation. -- It might be inferred that diethylene glycol has the same metabolic pathway as ethylene glycol and treatment of acute intoxication by diethylene-glycol should be the same as that of acute poisoning with ethylene glycol.
雄性大鼠二甘醇急性中毒（半数致死量）与草酸盐大量经尿排泄有关，碱化尿液和/或腹腔注射乙醇并补充水分可使草酸盐排泄量显著减少。仅通过大量补充水分或同时给予吡哆醇可显著降低中毒后五天内的死亡率，但大量补充水分同时进行碱化处理或腹腔注射乙醇（无论是否进行碱化处理）并补充水分则会抵消这种效果。—— 由此可以推断，二甘醇与乙二醇具有相同的代谢途径，二甘醇急性中毒的治疗方法应与乙二醇急性中毒相同。
