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Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen.

作者信息

Rollins D E, Buckpitt A R

出版信息

Toxicol Appl Pharmacol. 1979 Feb;47(2):331-9. doi: 10.1016/0041-008x(79)90328-4.

DOI:10.1016/0041-008x(79)90328-4
PMID:452025
Abstract
摘要

相似文献

1
Liver cytosol catalyzed conjugation of reduced glutathione with a reactive metabolite of acetaminophen.肝细胞溶质催化还原型谷胱甘肽与对乙酰氨基酚的一种活性代谢产物结合。
Toxicol Appl Pharmacol. 1979 Feb;47(2):331-9. doi: 10.1016/0041-008x(79)90328-4.
2
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3
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Acetaminophen-induced hepatotoxicity.
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Effect of L-ascorbic acid on acetaminophen-induced hepatotoxicity and covalent binding in hamsters. Evidence that in vitro covalent binding differs from that in vivo.L-抗坏血酸对仓鼠中对乙酰氨基酚诱导的肝毒性及共价结合的影响。体外共价结合与体内共价结合不同的证据。
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Studies comparing the kinetics of cysteine conjugation and protein binding of acetaminophen by hepatic microsomes from male mice.比较雄性小鼠肝脏微粒体中对乙酰氨基酚的半胱氨酸结合动力学和蛋白质结合的研究。
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Effect of acetone on the activation of acetaminophen.丙酮对乙酰氨基酚活化的影响。
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Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites.由CYP1A1催化的波纳替尼处置新途径，涉及潜在有毒代谢物的生成。
J Pharmacol Exp Ther. 2017 Oct;363(1):12-19. doi: 10.1124/jpet.117.243246.
2
Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice.丙硫氧嘧啶对乙酰氨基酚肝毒性的直接保护作用。大鼠和小鼠的体内及体外研究。
J Clin Invest. 1981 Mar;67(3):688-95. doi: 10.1172/JCI110084.
3
Paracetamol.对乙酰氨基酚
Postgrad Med J. 1980 Jul;56(657):459-73. doi: 10.1136/pgmj.56.657.459.
4
Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo.N-乙酰半胱氨酸对大鼠体内扑热息痛肝毒性保护作用的作用机制。
J Clin Invest. 1983 Apr;71(4):980-91. doi: 10.1172/jci110853.
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Liver injuries induced by cyclochlorotine isolated from Penicillium islandicum.由冰岛青霉分离出的环氯素所诱导的肝损伤。
Arch Toxicol. 1984 Mar;55(1):39-46. doi: 10.1007/BF00316584.
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Paracetamol overdosage. Pharmacological considerations and clinical management.对乙酰氨基酚过量。药理学考量与临床处理
Drugs. 1983 Mar;25(3):290-314. doi: 10.2165/00003495-198325030-00002.
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The role of glutathione in detoxication.谷胱甘肽在解毒中的作用。
Environ Health Perspect. 1983 Mar;49:59-69. doi: 10.1289/ehp.834959.