RNA在诱导肝微粒体混合功能氧化酶中的作用。
Role of RNA in induction of hepatic microsomal mixed function oxidases.
作者信息
Jacob S T, Scharf M B, Vessel E S
出版信息
Proc Natl Acad Sci U S A. 1974 Mar;71(3):704-7. doi: 10.1073/pnas.71.3.704.
Abstract
Induction of hepatic microsomal cytochrome P-450 and ethylmorphine N-demethylase activity by phenobarbital requires de novo synthesis of mRNA. Inhibition of RNA synthesis by alpha-amanitin given up to 8 hr after phenobarbital administration substantially inhibits this induction. However, beyond 8 hr after phenobarbital administration, RNA synthesis is not required for induction of these hepatic microsomal systems. Thus, mRNAs for cytochrome P-450 and ethylmorphine N-demethylase appear to be stable. Furthermore, these experiments reveal that the lag period for RNA synthesis approximates the length of the lag period for induction of the hepatic microsomal enzyme systems.
摘要
苯巴比妥诱导肝微粒体细胞色素P-450和N-脱甲基酶活性需要从头合成mRNA。在给予苯巴比妥后8小时内给予α-鹅膏蕈碱抑制RNA合成，可显著抑制这种诱导作用。然而，在给予苯巴比妥8小时后，这些肝微粒体系统的诱导不需要RNA合成。因此，细胞色素P-450和N-脱甲基酶的mRNA似乎是稳定的。此外，这些实验表明，RNA合成的延迟期近似于肝微粒体酶系统诱导的延迟期长度。
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引用本文的文献
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