蛋白质中谷氨酰胺和天冬酰胺残基的进化与分布
Evolution and the distribution of glutaminyl and asparaginyl residues in proteins.
作者信息
Robinson A B
出版信息
Proc Natl Acad Sci U S A. 1974 Mar;71(3):885-8. doi: 10.1073/pnas.71.3.885.
Abstract
Recent experiments on the deamidation of glutaminyl and asparaginyl residues in peptides and proteins support the hypothesis that these residues may serve as molecular clocks that control biological processes. A hypothesis is now offered that suggests that these molecular clocks are set by rejection or accumulation of appropriate sequences of residues including a glutaminyl or asparaginyl residue during evolution.
摘要
最近对肽和蛋白质中谷氨酰胺残基和天冬酰胺残基脱酰胺作用的实验支持了这样一种假说，即这些残基可能充当控制生物过程的分子时钟。现在提出一种假说，认为这些分子时钟是在进化过程中通过包含谷氨酰胺残基或天冬酰胺残基的适当残基序列的排斥或积累而设定的。
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本文引用的文献
1
Haemoglobin formation in rabbits.兔子体内血红蛋白的形成。
J Physiol. 1951 Feb;112(3-4):292-310. doi: 10.1113/jphysiol.1951.sp004530.
2
Biosynthesis of ribonuclease in mouse pancreas.小鼠胰腺中核糖核酸酶的生物合成。
J Biol Chem. 1960 May;235:1404-8.
3
Turnover of rat-liver mitochondria.大鼠肝脏线粒体的周转
Biochim Biophys Acta. 1961 Aug 5;51:356-60. doi: 10.1016/0006-3002(61)90177-9.
4
Metabolically inert proteins of the central and peripheral nervous system, muscle and tendon.中枢和外周神经系统、肌肉及肌腱的代谢惰性蛋白质。
Biochem J. 1961 Feb;78(2):272-82. doi: 10.1042/bj0780272.
5
The proteins of bovine pancreatic juice. II. Rates of synthesis in vivo of the cationic proteins.牛胰液中的蛋白质。II. 阳离子蛋白质的体内合成速率。
J Biol Chem. 1959 Feb;234(2):311-5.
6
The metabolism of myosin, the meromyosins, actin and tropomyosin in the rabbit.兔体内肌球蛋白、肌球蛋白亚基、肌动蛋白和原肌球蛋白的代谢
Biochim Biophys Acta. 1956 Apr;20(1):228-36. doi: 10.1016/0006-3002(56)90281-5.
7
The amino acid composition of mammalian collagen and gelatin.哺乳动物胶原蛋白和明胶的氨基酸组成。
Biochem J. 1955 Dec;61(4):589-600. doi: 10.1042/bj0610589.
8
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