Chen Y D, Hill T L
Proc Natl Acad Sci U S A. 1974 May;71(5):1982-6. doi: 10.1073/pnas.71.5.1982.
Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not meant to be realistic. Calculations were made near equilibrium, including linear and quadratic terms in a power series expansion, and arbitrarily far from equilibrium by direct numerical solution of the appropriate differential equation in the probability of cross-bridge attachment. The results obtained from the two different methods agree where they overlap near equilibrium. The efficiency of free energy conversion is emphasized, and the relation to linear irreversible thermodynamics is pointed out.
在等张收缩稳态下，基于简单的滑动细丝型双态肌肉模型，对产生的力和ATP通量进行了精确计算。目的是说明肌肉完整且自洽的分子模型的正确构建和应用。否则，该模型并非旨在写实。计算在接近平衡的状态下进行，包括幂级数展开中的线性和二次项，并且通过直接数值求解横桥附着概率的适当微分方程，在远离平衡的任意状态下进行计算。两种不同方法得到的结果在接近平衡处重叠时是一致的。强调了自由能转换的效率，并指出了与线性不可逆热力学的关系。
