雌激素急性撤除后卵清蛋白信使核糖核酸的快速失活
Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawal of estrogen.
作者信息
Palmiter R D, Carey N H
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2357-61. doi: 10.1073/pnas.71.6.2357.
Abstract
Synthesis of ovalbumin mRNA is induced and maintained in the avian oviduct by estrogen. When estrogen is rapidly removed from circulation, there is a general involution of the oviduct and an unusually rapid decay of ovalbumin mRNA activity. The kinetics of ovalbumin mRNA decay were not first order; instead, the rate of degradation increased about 10-fold over a 20-hr period after removal of estrogen. These results are in contrast with first-order decay kinetics observed for ovalbumin mRNA in estrogen-stimulated chicks (t(1/2) = about 24 hr) and in cell-free extracts. The degradative response triggered by hormonal withdrawal becomes more rapid between 1 and 4 days of estrogen-stimulated growth. We conclude that in the process of inducing egg-white protein synthesis, estrogen produces a cellular environment in which the egg-white protein mRNAs are relatively stable; removal of estrogen initiates cellular catabolism in a manner that is not understood.
摘要
雌激素可诱导并维持禽类输卵管中卵清蛋白mRNA的合成。当雌激素迅速从循环中去除时，输卵管会普遍退化，卵清蛋白mRNA活性也会异常快速衰减。卵清蛋白mRNA衰减的动力学并非一级动力学；相反，在去除雌激素后的20小时内，降解速率增加了约10倍。这些结果与在雌激素刺激的雏鸡（半衰期约为24小时）和无细胞提取物中观察到的卵清蛋白mRNA的一级衰减动力学形成对比。在雌激素刺激生长的1至4天之间，激素撤退引发的降解反应变得更快。我们得出结论，在诱导蛋清蛋白合成的过程中，雌激素产生了一种细胞环境，其中蛋清蛋白mRNA相对稳定；去除雌激素会引发细胞分解代谢，但其方式尚不清楚。
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