Feldman J M, Blalock J A, Foster L B
Acta Diabetol Lat. 1979 Jan-Mar;16(1):27-33. doi: 10.1007/BF02590760.
The purpose of this study was to compare the organ weights of obese-hyperglycemic (ob/ob) mice with the organ weights of their normal litter-mates. The absolute weights of the epididymal fat pads (white fat), interscapular fat pads (brown fat) and liver were greater in ob/ob mice than in normal mice. The weights of the kidneys and heart were similar in the 2 groups. The weights of the brain and testes were decreased in ob/ob mice when compared with normal mice. The weight gain of a second group of ob/ob mice was decreased by chronic food restriction resulting in a 26% reduction in weight when compared with ob/ob mice having unrestricted access to food. This substantially reduced the weight of the liver, but resulted in a minimal reduction in the weight of the epididymal fat pad. Food restriction did not alter the weight of the interscapular fat pads. It caused a relative reduction in kidney weight and a further absolute and relative reduction in testis weight.
本研究的目的是比较肥胖高血糖（ob/ob）小鼠与其正常同窝小鼠的器官重量。ob/ob小鼠附睾脂肪垫（白色脂肪）、肩胛间脂肪垫（棕色脂肪）和肝脏的绝对重量高于正常小鼠。两组小鼠的肾脏和心脏重量相似。与正常小鼠相比，ob/ob小鼠的脑和睾丸重量降低。第二组ob/ob小鼠通过长期食物限制使体重增加减少，与食物不受限制的ob/ob小鼠相比，体重降低了26%。这大幅降低了肝脏重量，但附睾脂肪垫重量仅略有降低。食物限制未改变肩胛间脂肪垫的重量。它导致肾脏重量相对降低，睾丸重量进一步绝对降低和相对降低。
