Schwenk H U, Völker H H, Ohlen J
Eur J Clin Invest. 1977 Oct;7(5):451-4. doi: 10.1111/j.1365-2362.1977.tb01633.x.
Chemotherapy was discontinued in thirteen children with acute lymphoblastic leukaemia after 2-3 years without relapse. In the following months, a continuous increase was observed in the serum alkaline phosphatase. A maximum was reached at different times but all patients had normal values again after 19 months. The rise in the total activity is due to an isolated increase of the bone isoenzyme. Increased enzyme activity in this post-therapy phase of the disease does not signify liver damage from the preceding chemotherapy, but rather is due to an increased osteoblast activity associated with a temporary increase in growth rate.
13名急性淋巴细胞白血病患儿在2至3年无复发后停止化疗。在接下来的几个月里，血清碱性磷酸酶持续升高。在不同时间达到最大值，但所有患者在19个月后酶值再次恢复正常。总活性升高是由于骨同工酶单独升高所致。在疾病的这个治疗后阶段，酶活性增加并不意味着先前化疗造成的肝损伤，而是由于成骨细胞活性增加，与生长速率暂时增加有关。
