Mir M A, Delamore I W
Br Med J. 1974 Sep 28;3(5934):775-7. doi: 10.1136/bmj.3.5934.775.
Two patients with acute myeloid leukaemia developed hypouricaemia during the period of their illness. Renal clearance studies showed that the hypouricaemia was associated with an increased urate clearance, renal aminoaciduria, and an episodic increase in phosphate clearance. These findings together with an inadequate suppression of urinary urate exceretion after the administration of pyrazinamide suggest proximal tubular dysfunction affecting reabsorption of a wide variety of substances. Ten more patients with acute leukaemia were studied and the results indicate that this lesion develops in a large proportion of patients with acute myeloid leukaemia.
两名急性髓细胞白血病患者在患病期间出现了低尿酸血症。肾脏清除率研究表明，低尿酸血症与尿酸清除率增加、肾性氨基酸尿以及磷酸盐清除率的间歇性增加有关。这些发现，再加上给予吡嗪酰胺后尿尿酸排泄抑制不足，提示近端肾小管功能障碍影响多种物质的重吸收。又对另外10名急性白血病患者进行了研究，结果表明，这种病变在很大比例的急性髓细胞白血病患者中出现。
