Mir M A
Postgrad Med J. 1977 May;53(619):257-9. doi: 10.1136/pgmj.53.619.257.
Serum lysozyme (muramidase) estimation is a simple, convenient and useful laboratory investigation. A review of the literature shows that lysozyme has been implicated as an aetiological factor in various disorders, and credited with being a prognostic indicator in acute myeloid leukaemia, but these promises have not been fulfilled. This low molecular weight protein is found in the urine of some patients with renal tubular disorders, but some workers have emphasized its importance as a causal agent in hypokalaemia of acute myeloid leukaemia. Research should be concentrated on muramidase as an expression of cell functions rather than as an aetiological factor. Hypokalaemia in acute myeloid leukaemia may be caused by an unidentified substance of molecular weight similar to that of lysozyme.
血清溶菌酶（胞壁质酶）测定是一项简单、便捷且有用的实验室检查。文献综述表明，溶菌酶已被认为是多种疾病的病因学因素，并被认为是急性髓系白血病的预后指标，但这些预期并未实现。这种低分子量蛋白质在一些肾小管疾病患者的尿液中被发现，但一些研究人员强调其作为急性髓系白血病低钾血症病因的重要性。研究应集中在将溶菌酶作为细胞功能的一种表达，而非病因学因素。急性髓系白血病中的低钾血症可能由一种分子量与溶菌酶相似的未知物质引起。
