一名肾病综合征患者获得性因子Ⅻ缺乏症。
Acquired factor XII Deficiency in a patient with nephrotic syndrome.
作者信息
van Royen E A, de Boer J E, Wilmink J M, Jenkins C S, ten Cate J W
出版信息
Acta Med Scand. 1979;205(6):535-9. doi: 10.1111/j.0954-6820.1979.tb06097.x.
Abstract
A patient with nephrotic syndrome and an acquired factor XII deficiency associated with a factor XII-like procoagulant activity in the urine was investigated. The urinary protein with procoagulant activity was isolated and comparative investigations revealed similar properties to plasma factor XII. It is suggested that the acquired coagulation defect may result from an insufficient biosynthetic capacity to compensate for the loss of factor XII in the urine.
摘要
对一名患有肾病综合征且伴有后天性凝血因子Ⅻ缺乏症并与尿液中类似凝血因子Ⅻ的促凝活性相关的患者进行了研究。分离出具有促凝活性的尿蛋白，对比研究显示其性质与血浆凝血因子Ⅻ相似。提示后天性凝血缺陷可能是由于生物合成能力不足，无法弥补尿液中凝血因子Ⅻ的丢失所致。
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