视网膜母细胞瘤基因的多效性作用。
Pleiotropic effects of the gene for retinoblastoma.
作者信息
Kitchin F D, Ellsworth R M
出版信息
J Med Genet. 1974 Sep;11(3):244-6. doi: 10.1136/jmg.11.3.244.
Abstract
Vigorous treatment of retinoblastoma in the last 30 years has resulted in a large population of survivors with useful vision, in which the late effects of genetically associated tumours can be seen. An increase in second primary tumours, mainly osteogenic sarcoma, has been found in those children who carry the germinal mutations, and not in the majority of survivors of unilateral disease. The findings indicate a pleiotropic effect of the retinoblastoma gene which may act as an initiator in two forms of neoplasia.
摘要
在过去30年里，对视网膜母细胞瘤的积极治疗已产生了大量拥有有用视力的幸存者，在这些幸存者中可以看到与基因相关肿瘤的晚期效应。在携带胚系突变的儿童中发现了第二原发性肿瘤（主要是骨肉瘤）的增加，而在单侧疾病的大多数幸存者中未发现这种情况。这些发现表明视网膜母细胞瘤基因具有多效性作用，它可能在两种肿瘤形成形式中充当启动子。
相似文献
1
Pleiotropic effects of the gene for retinoblastoma.
J Med Genet. 1974 Sep;11(3):244-6. doi: 10.1136/jmg.11.3.244.
2
Not radiation-induced osteosarcoma following bilateral retinoblastoma. Report of a sporadic case.
G Chir. 1988 Nov;9(11):788-90.
3
[Bone sarcoma and malignant tumors of the retina].
Bull Cancer. 1985;72(1):16-24.
4
Retinoblastoma and osteogenic sarcoma.
Ophthalmologica. 1977;175(4):185-91. doi: 10.1159/000308656.
5
Tumor suppressor gene (Rb and p53) mutations in osteosarcoma.
Pediatr Hematol Oncol. 1992 Apr-Jun;9(2):ix-x. doi: 10.3109/08880019209018322.
6
Retinoblastoma and osteosarcoma: the prototypic cancer family.
Acta Paediatr Jpn. 1987 Aug;29(4):526-33. doi: 10.1111/j.1442-200x.1987.tb02233.x.
7
Retinoblastoma: epidemiologic characteristics.
N Engl J Med. 1971 Aug 5;285(6):307-11. doi: 10.1056/NEJM197108052850602.
8
Retinoblastoma associated with other primary malignant tumours.
Trans Ophthalmol Soc U K (1962). 1974;94(4):938-44.
9
Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.
Am J Hum Genet. 1986 Jan;38(1):59-66.
10
Molecular biology of the human retinoblastoma gene.
Immunol Ser. 1990;51:169-200.
引用本文的文献
1
De Novo RB1 Germline Variant in Retinoblastoma with Two Subsequent Independent Neoplasms: Case Report and Literature Review.
Int J Mol Sci. 2024 Nov 17;25(22):12338. doi: 10.3390/ijms252212338.
2
Subsequent Malignant Neoplasms in Retinoblastoma Survivors.
Cancers (Basel). 2021 Mar 10;13(6):1200. doi: 10.3390/cancers13061200.
3
Identification and characterization of small molecule antagonists of pRb inactivation by viral oncoproteins.
Chem Biol. 2012 Apr 20;19(4):518-28. doi: 10.1016/j.chembiol.2012.03.007.
4
Osteosarcoma development and stem cell differentiation.
Clin Orthop Relat Res. 2008 Sep;466(9):2114-30. doi: 10.1007/s11999-008-0335-z. Epub 2008 Jun 18.
5
Establishment and characterization of OS 99-1, a cell line derived from a highly aggressive primary human osteosarcoma.
In Vitro Cell Dev Biol Anim. 2008 Mar-Apr;44(3-4):87-95. doi: 10.1007/s11626-007-9075-8. Epub 2008 Feb 5.
6
Bone metastasis from retinoblastoma.
Iowa Orthop J. 1993;13:214-7.
7
The risk of cancer in relatives of patients with brain neoplasm.
Acta Neurochir (Wien). 1994;131(3-4):226-8. doi: 10.1007/BF01808618.
8
Excess of cancer deaths in grandparents of patients with retinoblastoma.
J Med Genet. 1980 Apr;17(2):95-101. doi: 10.1136/jmg.17.2.95.
9
Recent views on genetic factors in retinoblastoma.
J Med Genet. 1980 Oct;17(5):386-7. doi: 10.1136/jmg.17.5.386.
10
Genetics of Wilms' tumor.
Hum Genet. 1981;57(3):231-46. doi: 10.1007/BF00278936.
本文引用的文献
1
ANALYSIS OF CYTOGENESIS IN CHICK RETINA BY TRITIATED THYMIDINE AUTORADIOGRAPHY.
Arch Histol Jpn. 1963 May;23:359-66. doi: 10.1679/aohc1950.23.359.
2
Radiation induced neoplasia following external beam therapy for children with retinoblastoma.
Am J Roentgenol Radium Ther Nucl Med. 1969 Mar;105(3):529-35. doi: 10.2214/ajr.105.3.529.
3
Cessation of DNA synthesis in retinal ganglion cells correlated with the time of specification of their central conections.
Dev Biol. 1968 Feb;17(2):219-32. doi: 10.1016/0012-1606(68)90062-6.
4
Dq-, Dr and retinoblastoma.
Humangenetik. 1970;10(3):209-17. doi: 10.1007/BF00295782.
5
The practical management of retinoblastoma.
Trans Am Ophthalmol Soc. 1969;67:462-534.
6
Retinoblastoma: epidemiologic characteristics.
N Engl J Med. 1971 Aug 5;285(6):307-11. doi: 10.1056/NEJM197108052850602.
7
Mutation and cancer: statistical study of retinoblastoma.
Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3. doi: 10.1073/pnas.68.4.820.
8
Ultraviolet light, DNA repair and skin carcinogenesis in man.
Fed Proc. 1971 Nov-Dec;30(6):1766-71.
9
Histogenesis of the retina in the killifish, Fundulus heteroclitus.
J Comp Neurol. 1972 Mar;144(3):373-80. doi: 10.1002/cne.901440308.
Zotero 插件