Bonaïti-Pellié C, Briard-Guillemot M L
J Med Genet. 1980 Apr;17(2):95-101. doi: 10.1136/jmg.17.2.95.
An excess of cancer deaths was found in grandparents of 308 children with retinoblastoma. This excess was found in all types of retinoblastoma, unilateral and bilateral, sporadic and familial. We postulated that the excess could be the result of a factor of susceptibility to cancer, different from the retinoblastoma gene, which would increase the mutation rate in retinal and germ cells as well as in other tissues.
在308名视网膜母细胞瘤患儿的祖父母中发现了癌症死亡人数过多的情况。在所有类型的视网膜母细胞瘤中都发现了这种过多情况，包括单侧和双侧、散发性和家族性的。我们推测，这种过多可能是由于一种不同于视网膜母细胞瘤基因的癌症易感性因素导致的，该因素会增加视网膜细胞、生殖细胞以及其他组织中的突变率。
