Mejia L A, Hodges R E, Rucker R B
Am J Clin Nutr. 1979 Jul;32(7):1439-44. doi: 10.1093/ajcn/32.7.1439.
Young rats weighing 150 g (initial weight) were fed diets sufficient or deficient in vitamin A. Postweaning rats were used in order to retard the rapid onset of vitamin A deficiency. The effects of the deficiency were studied with respect to impairment of hematopoietic function and anemia. Values for hemoglobin and hematocrit provided evidence of anemia before the signs of severe vitamin A deficiency became apparent. These included alopecia, ocular lesions, and low levels of retinol in plasma and liver. At the point where liver stores of vitamin A were virtually depleted, however, estimates for serum iron, hematocrit, and hemoglobin were elevated to control levels. The latter phenomenon appeared to result from hemoconcentration. These data suggest that anemia may be a component of vitamin A deficiency, but might be masked by the dehydration that accompanies severe depletion of vitamin A.
体重150克（初始体重）的幼鼠被喂食维生素A充足或缺乏的饲料。使用断奶后的大鼠以延缓维生素A缺乏症的快速发作。研究了维生素A缺乏对造血功能损害和贫血的影响。在严重维生素A缺乏的体征出现之前，血红蛋白和血细胞比容值就提供了贫血的证据。这些体征包括脱发、眼部病变以及血浆和肝脏中视黄醇水平低。然而，在肝脏中的维生素A储备几乎耗尽时，血清铁、血细胞比容和血红蛋白的估计值升高到了对照水平。后一种现象似乎是由血液浓缩导致的。这些数据表明，贫血可能是维生素A缺乏症的一个组成部分，但可能会被严重维生素A缺乏伴随的脱水所掩盖。
